The length of time to notice Qualia's effects can vary, but many report a discernible increase in focus and clarity within as little as 20 minutes.
The short term effects will last between a few hours and a few days depending on how much you take and your specific metabolism. The long term effects like more neurons and synaptic connections can last a long time if you take care of your brain.
Qualia was designed to support the integrity of the natural pathways that mediate cognitive and performative functions, leaving a healthier, more balanced regulatory system even after discontinuing use. So while some of the ingredients give you immediate benefits or benefits for a few days, other ingredients are busy actually building more neurons and synapses, repairing cell walls, etc. The result is that if you use Qualia for months, you should benefit from a system upgrade – not just an enhancement.